Ruud van Nistelrooy takes charge of United for the final time as interim head coach on what will be a big occasion as fans get ready to usher in the start of a new era.
Amorim will take over a team in the bottom half of the Premier League table but a win against Leicester would further lift the mood around the club.
Here’s everything you need to know about the game…
Date, kick-off time and venue
Manchester United vs Leicester is scheduled for a 2pm GMT on Sunday 10 November 2024.
Old Trafford in Manchester will host.
Where to watch Manchester United vs Leicester
TV channel and live stream: The game will not be broadcast in the UK.
Free highlights: Match of the Day 2, however, will show highlights when it airs at 10.30pm GMT on BBC One.
LIVE coverage: Follow the action LIVE with Standard Sport’s dedicated match blog!
Manchester United vs Leicester team news
Manchester United XI: Onana, Mazraoui, De Ligt, Martinez, Dalot, Casemiro, Ugarte, Amad, Fernandes, Rashford, Hojlund
Subs: Bayindir, Heaton, Evans, Lindelof, Eriksen, Mount, Antony, Garnacho, Zirkzee
Leicester XI: Hermansen, Justin, Vestergaard, Faes, Kristiansen, Winks, Soumare, Ndidi, Fatawu, Buonanotte, Ayew
Subs: Ward, Coady, Okoli, Chodhury, Skipp, McAteer, El Khannouss, Mavidi, Edouard
Manchester United vs Leicester prediction
While United are hardly covering themselves in glory right now, slipping at home here would be a major shock.
Head to head (h2h) history and results
Manchester United vs Leicester odds
Odds via Betfair and subject to change.