With title rivals Arsenal and Liverpool meeting at Emirates Stadium on Sunday, City can move two points clear if they win at Emirates Stadium.
Southampton have managed just one point in their first eight games and Saints manager Russell Martin is under increasing pressure.
Erling Haaland has gone three Premier League games without a goal and, after his brace in the Champions League in midweek, will be licking his lips at the prospect of facing Southampton.
Here’s everything you need to know…
Date, kick-off time and venue
Man City vs Southampton is scheduled for a 3pm BST kick-off on Saturday, October 26, 2024.
The match will take place at Etihad Stadium in Manchester.
Where to watch Man City vs Southampton
Free highlights: The Sky Sports app and YouTube channel will show highlights from 5.15pm with Match of the Day broadcasting on BBC One at 10.20pm BST.
Man City vs Southampton team news
Erling Haaland is back amongst the goal as Man City prepare for Southampton
REUTERS
Saints will be missing Ryan Fraser following his red card during Saturday’s 3-2 defeat to Leicester. Yukinari Sugawara and Ross Stewart are doubts, while Will Smallbone and Gavin Bazunu are out.
Man City vs Southampton prediction
This could be a cricket score. The reigning champions against, arguably, the worst team in the league, anything less than a thumping win for City would be a disappointment.
Haaland will have no better opportunity to get back amongst the goals, and his supporting cast will likely feel the same.
Head to head (h2h) history and results
Man City vs Southampton match odds
Odds via Betfair (subject to change).