The reigning European champions booked their place in the quarter-finals with a couple of games to spare and ensured they will finish as group winners by beating Denmark last time out.
As for the Swiss, relegation to League B was confirmed on Friday night after conceding a late equaliser to draw at home to Serbia.
Which leaves this game as effectively a dead-rubber, so it remains to be seen what starting lineups are selected by Luis de la Fuente and Murat Yakin respectively as there is an opportunity for some rotation.
When the two nations met in September, Spain cruised to a 4-1 victory despite playing for more than an hour with 10 men, with Fabian Ruiz the pick of the bunch by netting a brace.
Where to watch Spain vs Switzerland
TV channel: In the UK, the game will not be televised.
Live stream: Fans can catch the contest live online via the Viaplay International YouTube channel. Kick-off is at 7.45pm GMT.
