Chelsea are used to playing against City for silverware having faced them in both domestic cup finals in 2022.
They have been rivals in the Women’s Super League too with Chelsea pipping City to the title last season on goal difference.
But when the clubs were drawn against each other in the Champions League, even the players couldn’t believe how the fixtures had panned out.
“We were all like ‘that’s crazy!'” Chelsea forward Aggie Beever-Jones told BBC Radio London.
Defender Niamh Charles added: “It’s so unique. It will be interesting for the fans.
“As a player, we’re used to changing opposition all the time. But it is what it is. Each game is a separate thing and you attack each one.”
Chelsea manager Sonia Bompastor at least understands what it feels like to play a rival regularly in a short space of time.
While she has never encountered a four-game successive run, her former Lyon side frequently came up against Paris St-Germain in multiple competitions.
Last year, the French sides met three times in a month – and the same happened the season before.
“There was a lot of similarity but we had more space between the games. Against Manchester City it will be four games in 12 days and in three different competitions,” Bompastor told BBC Radio 5 Live.
“It is a rare thing in football but we are really excited and looking forward to it. Every game will be different. It will be 50-50 from the beginning to the end.
“Sometimes when you play [teams again] three days after, everything is fresh so it’s sometimes harder. But it is for both teams, so it is the same for them.”
