Demi Moore, 61, and co-star Margaret Qualley, 29, can’t wipe the smiles off their faces as they reunite on the red carpet at the Academy Museum Gala after their horror film The Substance

Demi Moore and her The Substance co-star Margaret Qualley reunited at the Academy Museum Gala on Saturday evening.

The Hollywood actress, 61, couldn’t wipe the smile off her face as she joined Margaret on the red carpet at the Academy Museum of Motion Pictures.

Demi looked sensational in a purple plunging gown, adorned with a risqué thigh-high split leg.

Meanwhile, Margaret flashed her long legs in a black strappy gown, teamed with a mesh skirt.

The actresses were in fits of laughter as they shared a sweet moment on the red carpet. 

Demi Moore, 61, and her The Substance co-star Margaret Qualley, 29, reunited at the Academy Museum Gala on Saturday evening

The Hollywood actress couldn’t wipe the smile off her face as she joined Margaret on the red carpet at the Academy Museum of Motion Pictures

Demi stars in the horror film The Substance – which is directed, written and produced by French filmmaker Coralie Fargeat – as Elisabeth Sparkle, a former Oscar winner who has settled in TV with a popular aerobics program that she hosts.

But when she turns 50, she in unceremoniously fired from her show as the network — led by an over-the-top Dennis Quaid — seeks a younger host, even though the show seems to be getting solid ratings.

When Elisabeth learns of a mysterious drug called The Substance that can help her stay young, she jumps at the opportunity.

The shadowy substance causes her to grow a second, younger body (played by Margaret), which she can inhabit for seven days at time, though she must return to her body for a full week off before alternating again.

Her younger self turns out to be a hit with the network and nabs her old show, but Elisabeth realizes that her younger self has trouble only using her body for seven days at a time, and their delayed transfers begin to have significant, stomach-churning impacts on Elisabeth’s body.

The film has been applauded by film fans for being a return to the body horror sub-genre pioneered by filmmakers including David Cronenberg (The Fly, Videodrome), Brian Yuzna (Society) and Stuart Gordon (Re-Animator, From Beyond).

Demi, who undergoes multiple shocking physical transformations in The Substance, has received some of the best reviews of her career, while Margaret has capped off a string of acclaimed performances with auteur filmmakers. 

The film features an impressive amount of gore for an international co-production that played at the Cannes Film Festival and won its Best Screenplay award earlier this year.

The actresses were in fits of laughter as they shared a sweet moment on the red carpet 

Demi looked sensational in a purple plunging gown, adorned with a risqué thigh-high split leg

Meanwhile, Margaret flashed her long legs in a black strappy gown, teamed with a mesh skirt

Demi stars as an actress-turned-aerobics host who is fired from her TV show when she turns 50. Despairing, she turns to a mysterious drug called The Substance; still from The Substance

The drug creates a younger alternate version of herself (Qualley) that she can inhabit for seven days at a time. But the younger version has a mind of her own, and she starts staying past the seven days, which has a stomach-churning effect on Demi’s body; still from The Substance

While that has made a film a hit with horror lovers, it has also left some unprepared audiences ‘traumatized’ due to its buckets of blood and mangled limbs.’

Demi’s ex-husband Bruce Willis was forced to retire as he battles frontotemporal dementia (FTD) and aphasia, which has reportedly left him unable to speak, in recent months.

‘You know, I’ve said this before. The disease is what the disease is. And I think you have to be in real deep acceptance of what that is,’ Moore told the audience during a live discussion moderated by Alina Cho, as reported by People. ‘But for where he’s at, he is stable.’